The reason for lobes of tablet machine and its solution

Tablet machine is the vibration or by placing, there are from the waist split called the lumbar fissure, split from the top called the top crack, lumbar fissure and the top crack, collectively referred to as lobes. Thursday, September 29, 2016

 Tablet machine is the vibration or by placing, there are from the waist split called the lumbar fissure, split from the top called the top crack, lumbar fissure and the top crack, collectively referred to as lobes.

  1. Pressure is too large, the particles by the pressure increases, the degree of expansion also increased, the adhesive binding can not inhibit its expansion, it caused lobes, should reduce the pressure treatment.
  2. On the red and die hole substandard requirements. The use of the course of time the dies, increasing wear, resulting in the punch and mold hole anastomosis is not straight, with sharp sharp inward curling, the pressure will be uneven part of the film too much pressure, causing the top crack or mold Aliasing distortion.
  3. Ablet machine speed too fast, tablet compression time is too short, so that the film suddenly compressed and compressed, and then suddenly the expansion and lobes. Corresponding to the increase in preload preload time.
  4. Improper selection of adhesives, granulation when the adhesive is too small, less than the viscosity of the particles dry, more fine powder is too dry particles too hard, can cause disintegration difficulties, one-sided pitting, it is necessary to join the adhesive Appropriate; such as too much powder, can sift out a little; particles too hard, rework should be re-granulation and additional disintegrating agent.
  5. Particles are not required, loose texture, fine powder caused by too much lobes, the method should be modified to adjust the concentration and dosage of adhesives to improve the granulation method to be overcome.
  6. Particles are too dry, with crystal water loss of drugs caused by too much lobes, the same solution and loose pieces.
  7. Some crystalline drugs, not been fully crushed. Such drugs can be fully crushed after granulation.
  8. Compression chamber room temperature is low, low humidity, easy to cause lobes, especially the poor viscosity of the drug prone. Adjust the temperature and humidity system accordingly.

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